Rabbit Anti-Human KSHV G-Protein Coupled Receptor pAb

Kaposi’s sarcoma-associated Herpesvirus (KSHV) or Human Herpesvirus 8, HHV8), is a gamma Herpesvirus that contain an open reading frame encoding a G Protein Coupled Receptor (GPCR) with putative 7 transmembrane domains. This GPCR has been shown to bind a number of chemokines including IL-8, NAP-2, PF-4, MGSA/GroA, I-309, RANTES, MCP-1, and MIP-1b. The receptor is constitutively activated without chemokine binding, and it stimulates cell proliferation. KSHV GPCR is also a viral oncogene that stimulates angiogenesis through induction of VEGF expression. IP-10, a chemokine, can inhibit constitutively activated KSHV GPCR.

Recombinant KSHV GPCR N-terminal fragment (amino acids 1-41)

Centrifuge the vial prior to opening. Reconstitute to 1.0 mg/mL by adding 200 ul sterile distilled water.

Human KSHV GPCR