Rat Anti-Mouse TLR4 Clone MTS510 Biotin mAb

The monoclonal antibody MTS510 reacts with the Toll-like receptor 4 (TLR4, CD284) /MD-2. TLRs are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila, toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defense. In mammals, TLRs identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defence to pathogens. TLR4 has been identified next to MD-2 and CD14 as a receptor that is central to the innate immune response to lipopolysaccharides (LPS) of Gram-negative bacteria. The monoclonal antibody MTS510 reacts preferentially, especially in flow cytometry, with mouse TLR4 that is associated with MD-2. MTS510 is a TLR4 function-blocking antibody that is useful for studies on the role of TLR4 as a receptor for LPS induced cytokine production by TLR4 bearing cells. The antibody was shown to coprecipitate MD-2 (30 kDa) with TLR4 (100 kDa).

Product should be store at 4C. Under recommended storage conditions, product should be stable for one year.