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Sonidegib diphosphate

Sonidegib diphosphate

€65.00

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Item no.	HY-16582-10mg
Manufacturer	MedChem Express
CASRN	1218778-77-8
Amount	10 mg
Category	Oncology Neuroscience Neuroinflammation Inhibitors & Compound Libraries Small Molecules By Organ Colorectal Cancer Heart & Blood Cancer Bone Cancer
Type	Inhibitors
Clone	N/A
Specific against	other
Purity	99.73
Formula	C26H32F3N3O11P2
Citations	J Genet Genomics. 2018 May 20;45(5):237-246. Nat Med. 2018 Nov;24(11):1752-1761. Patent. US20180263995A1. bioRxiv. 2023 Nov 6. Cell Physiol Biochem. 2018;47(4):1352-1364. [1]Pan S, et al. Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist. ACS Med Chem Lett. 2010 Mar 16;1(3):130-4. [2]Irvine DA, et al. Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Sci Rep. 2016 May 9;6:25476.
Smiles	O=C(C1=C(C)C(C(C=C2)=CC=C2OC(F)(F)F)=CC=C1)NC3=CC=C(N=C3)N4C[C@@H](C)O[C@@H](C)C4.O=P(O)(O)O.O=P(O)(O)O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Erismodegib (diphosphate); LDE225 (diphosphate); NVP-LDE225 (diphosphate)
Available
Product Description	Sonidegib diphosphate (Erismodegib diphosphate) is a potent and selective Smo antagonist with IC50 of 1.3 nM and 2.5 nM for mouse and human Smo in binding assay, respectively[1].
StorageTemperature	4°C (Powder, sealed storage, away from moisture)
Shipping	Room Temperature
Manufacturers Applications	Cancer-programmed cell death
Molecular Weight	681.49
Clinical Information	Launched
Solubility	DMSO : 100 mg/mL (ultrasonic)\|H2O : 0.25 mg/mL (ultrasonic)
Pathway	Stem Cell/Wnt
Manufacturers Product type	Reference compound

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HY-16582-10mg-safety-datasheet.pdf