Mouse CD10/Neprilysin ELISA Kit PicoKine®

PicoKine® ELISA Kits

Mouse CD10/Neprilysin ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Mme in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Neprilysin, also known as membrane metallo-endopeptidase, neutral endopeptidase (NEP), CD10, and common acute lymphoblastic leukemia antigen (CALLA), is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably theamyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer's disease, this gene is localized to human chromosome 3 by study of somatic cell hybrids and regionalized the location to 3q21-q27 by in situ hybridization. By cDNA transfection analysis, Neprilysin is confirmed as a functional neutral endopeptidase of the type that has previously been called enkephalinase. Neprilysin has also been called atriopeptidase. Atriopeptidase specifically degrades atrial natriuretic factor. A specific enzyme inhibitor was developed and reported that it had effects similar to those of low-dose ANF infusion. These effects include diuresis, natriuresis, vasodilatation, and suppression of the renin-angiotensin-aldosterone system.

Dilution ratio of 1:1, concentration in serum and plasma is around 200 pg/ml.

There is no detectable cross-reactivity with other relevant proteins.

polyclonal antibody from goat|polyclonal antibody from goat

heparin or EDTA

85702 MW

Cell membrane; Single-pass type II membrane protein.