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Human TNFSF14/LIGHT ELISA Kit PicoKine®

Human TNFSF14/LIGHT ELISA Kit PicoKine®

€477.00

Excl. VAT

Item no.	BOS-EK0990
Manufacturer	Boster
Amount	96 wells/kit, with removable strips.
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Metabolism Diabetes By Cell Type Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis ELISA ELISA & Immunoassays ELISA Kits Immunoassay By Organ Lung Cancer
Type	Elisa-Kit
Applications	ELISA
Specific against	Human (Homo sapiens)
Sensitivity	<10 pg/ml
ECLASS 10.1	32160605
ECLASS 11.0	32160605
UNSPSC	41116126
Alias	Tumor necrosis factor ligand superfamily member 14;Herpes virus entry mediator ligand;HVEM-L;Herpesvirus entry mediator ligand;CD258;Tumor necrosis factor ligand superfamily member 14, membrane form;Tumor necrosis factor ligand superfamily member 14, soluble form;TNFSF14;HVEML, LIGHT;UNQ391/PRO726;
Available
Manufacturers Product Category	PicoKine® ELISA Kits
Manufacturers Research Category	Adaptive Immunity, Cytokines, Immunology, Innate Immunity, T Cells, TNF Superfamily
Short Description	Human TNFSF14/LIGHT ELISA Kit PicoKine® (96 Tests). Quantitate Human TNFSF14 in cell culture supernatants, serum, plasma (heparin, EDTA) and saliva. Sensitivity: 10pg/ml.
Description	Human TNFSF14/LIGHT ELISA Kit PicoKine® (96 Tests). Quantitate Human TNFSF14 in cell culture supernatants, serum, plasma (heparin, EDTA) and saliva. Sensitivity: 10pg/ml.
Background	Tumor necrosis factor ligand superfamily member 14 is a protein that in humans is encoded by the TNFSF14 gene. TNFSF14 has also been designated as CD258, as well as LIGHT. It was mapped on chromosome 19p13.3. The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported.
Gene Name	TNFSF14
Application Details	Dilution ratio of 1:1, concentration in serum and plasma is 0-259 pg/ml.
Immunogen	Expression system for standard: NS0; Immunogen sequence: D74-V240
Cross-reactivity	There is no detectable cross-reactivity with other relevant proteins.
Sample Type	cell culture supernatants, serum, plasma (heparin, EDTA) and saliva.
Capture antibody\|Detection antibody	monoclonal antibody from mouse\|polyclonal antibody from goat
Storage	Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)
Anticoagulant	heparin or EDTA
Gene Full Name	Tumor necrosis factor ligand superfamily member 14
Molecular Weight	26350 MW
Protein Function	Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
Subcellular Localization	Tumor necrosis factor ligand superfamily member 14, membrane form: Cell membrane; Single-pass type II membrane protein.
Tissue Specificity	Predominantly expressed in the spleen but also found in the brain. Weakly expressed in peripheral lymphoid tissues and in heart, placenta, liver, lung, appendix, and kidney, and no expression seen in fetal tissues, endocrine glands, or nonhematopoietic tumor lines.
Protein Name	Tumor necrosis factor ligand superfamily member 14

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