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Anti-NOX2/gp91phox/CYBB Antibody

Anti-NOX2/gp91phox/CYBB Antibody

€366.00

Excl. VAT

Item no.	BOS-PA1667
Manufacturer	Boster
Amount	100 ug/vial
Category	Neuroscience Molecular Targets for Neuroscience Antibodies Immunohistochemistry Western Blot Primary Antibodies
Type	Antibody Polyclonal
Format	Lyophilized
Applications	WB, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Cytochrome b-245 heavy chain;1.-.-.-;CGD91-phox;Cytochrome b (558) subunit beta;Cytochrome b558 subunit beta;Heme-binding membrane glycoprotein gp91phox;NADPH oxidase 2;Neutrophil cytochrome b 91 kDa polypeptide;Superoxide-generating NADPH oxidase heavy chain subunit;gp91-1;gp91-phox;p22 phagocyte B-cytochrome;CYBB;NOX2;
Similar products	beta polypeptide antibody, AMCBX2 antibody, CGD antibody, CGD91-phox antibody, CY24B_HUMAN antibody, CYBB antibody, Cytochrome b 245, Cytochrome b(558) beta chain antibody, Cytochrome b(558) subunit beta antibody, Cytochrome b-245 heavy chain antibody, Cytochrome b558 subunit beta antibody, GP91 PHOX antibody, gp91-1 antibody, gp91-phox antibody, GP91PHOX antibody, Heme-binding membrane glycoprotein gp91phox antibody, NADPH oxidase 2 antibody, Neutrophil cytochrome b 91 kDa polypeptide antibody, NOX2 antibody, p22 phagocyte B-cytochrome antibody, P91 PHOX antibody, p91-PHOX antibody, Superoxide-generating NADPH oxidase heavy chain subunit antibody
Available
Manufacturers Product Category	Primary Antibodies, Rabbit Polyclonal Antibodies
Manufacturers Research Category	Adaptive Immunity, Cancer, Cancer Metabolism, Immunology, Metabolism, T Cells
Short Description	Boster Bio Anti-NOX2/gp91phox/CYBB Antibody catalog # PA1667. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Description	Boster Bio Anti-NOX2/gp91phox/CYBB Antibody catalog # PA1667. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.
Background	NOX2 (NADPH OXIDASE 2), also called CYBB (CYTOCHROME b (-245), BETA SUBUNIT), p91-PHOX or GP91-1, is a human gene encoding a glycoprotein.NOX2 is an essential component of phagocytic NADPH-oxidase, a membrane-bound enzyme complex that generates large quantities of microbicidal superoxide and other oxidants upon activation. It is mapped on Xp11.4. NOX2 is a heterodimer composed of an alpha chain of relative molecular mass 23 kD and a beta chain of 76 to 82 kD. NOX2 assembled on DC phagosomes in a gp91-phox subunit-dependent manner, and that reactive oxygen species were produced in a more sustained manner in immature DC phagosomes than in macrophage phagosomes. As a major player in innate immune responses in neutrophils, NOX2 is also involved in adaptive immunity through its activity in DCs. In heart cells, physiologic stretch rapidly activates reduced-form NOX2 to produce reactive oxygen species (ROS) in a process dependent on microtubules (X-ROS signaling).
Gene Name	CYBB
Application Details	Western blot, 0.1-0.5μg/ml, Human Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Mouse, Rat, By Heat
Application Notes	Tested Species: In-house tested species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Other applications have not been tested. Optimal dilutions should be determined by end users.
Predicted Reactivity	Hamster
Clonality	Polyclonal
Concentration	Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.
Contents	Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
Immunogen	A synthetic peptide corresponding to a sequence in the middle region of human NOX2, identical to the related rat and mouse sequences.
Purification	Immunogen affinity purified.
Cross-reactivity	No cross-reactivity with other proteins
Storage	Store at -20˚C for one year from date of receipt. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for six months. Avoid repeated freeze-thaw cycles.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Gene Full Name	Cytochrome b-245 heavy chain
Molecular Weight	65336 MW
Protein Function	Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H (+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.
Subcellular Localization	Cell membrane; Multi-pass membrane protein.
Tissue Specificity	Detected in neutrophils (at protein level)..
Protein Name	Cytochrome b-245 heavy chain
Sequence Similarities	Contains 1 FAD-binding FR-type domain.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.