NTRK3 polyclonal antibody

Q16288

The Trk proto-oncogene encodes a tyrosine protein kinase, Trk A, also designated Trk gp140, that serves as a receptor for certain neurotrophic factors including nerve growth factor (NGF) and neurotrophin-3 (NT-3). Trk B is a tyrosine kinase gene highly related to Trk A. Trk B expression is confined to tissues within the central and peripheral nervous systems. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on Tyrosine of Trk B gp145, one of the receptors encoded by Trk B, although BDNF elicits a response at least two orders of magnitude greater than NT-3. Thus it appears that Trk B gp145 may represent a neurotrophic receptor for BDNF and NT-3. The third member of the Trk family of tyrosine kinases, Trk C, is mainly expressed in nervous tissue, and is a functional receptor for NT-3. Four forms of Trk C are produced by alternative splicing. Isoform A is full length Trk C, isoform B differs from A between amino acids 529 to 612 and is missing amino acids 613 to 839. Trk C, isoform C is missing amino acids 712 to 725 and isoform D is missing amino acids 402 to 410.

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

NTRK3 pAb detects endogenous levels of NTRK3 protein.

ca. 94 kDa

ETS related protein neurotrophic receptor tyrosine kinase fusion, ETV6 NTRK3 fusion, GP145 TrkC, gp145(trkC), GP145-TrkC, GP145TrkC, Neurotrophic tyrosine kinase receptor type 3, neurotrophin 3 receptor, NT 3 growth factor receptor, NT 3 growth factor receptor precursor, NT 3 receptor, NT-3 growth factor receptor, NTRK3, NTRK3_HUMAN, OTTHUMP00000192915, TRK C, Trk-C, TrkC tyrosine kinase, tyrosine kinase receptor C,