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ICOS polyclonal antibody

ICOS polyclonal antibody

€472.00

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Item no.	BS6795-100
Manufacturer	Bioworld Technology, Inc
Amount	100ul
Category	Neuroscience Neural Lineage Markers Neuroinflammation Antibodies Immunohistochemistry Western Blot Immunofluorescence Primary Antibodies
Type	Antibody Polyclonal
Applications	WB, IF, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, CD278, ICOS, AILIM
Similar products	ICOS
Available
Swiss-Prot	Q9Y6W8
Application all	WB: 1:500ca.1:2000 IHC/IF: 1:50ca.1:200
Background	The B7-related cell surface proteins CD80 (B7-1) and CD86 (B7-2) are expressed on antigen presenting cells. CD80 and CD86 bind to the homologous T cell receptors CD28 and CTLA-4 (cytotoxic T lymphocyte-associated protein-4) and trigger costimulatory signals for optimal T cell activation. CTLA-4 shares 31% overall amino acid identity with CD28 and it has been proposed that CD28 and CTLA-4 are functionally redundant. ICOS (inducible co-stimulator) is related to CD28 and CTLA-4, and these three proteins are thought to compose a receptor family. ICOS stimulation enhances T cell responses and superinduces the synthesis of IL-10, but it does not induce IL-2 upregulation.
Product	1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Purification and Purity	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability	Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Specificity	ICOS pAb detects endogenous levels of ICOS protein.
WB	Western blot analysis of extracts of various cell lines, using ICOS antibody.
IF	Immunofluorescence analysis of MCF7 cells, using ICOS polyclonal antibody
BiowMW	ca. 22 kDa
Note	For research use only, not for use in diagnostic procedure.
Alternative Name	Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, CD278, ICOS, AILIM
Immunogen	Recombinant full length Human ICOS.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100ul

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