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Anti-Mouse CD70 SAFIRE Purified 500 ug

Anti-Mouse CD70 SAFIRE Purified 500 ug

€369.00

Excl. VAT

Item no.	02812-25-500
Manufacturer	BioGems
Amount	500 ug
Category	Neuroscience Neural Lineage Markers Aging & Neurological Disorders Antibodies Flow Cytometry Primary Antibodies
Type	Antibody
Format	SAFIRE Purified
Applications	FC
Clone	FR70
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG2b kappa
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Description	The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily. CD70 is the ligand for CD27 and is expressed on dendritic cells, activated B cell, and a subset of activated T cells at lower levels. Its main role is in regulating B cell activation and immunoglobulin synthesis. CD70 expressing cells are able to co-stimulate T cell proliferation and upregulate cytokine production. The FR70 antibody is reported to block the binding of CD70 to CD27
Research Interest	Adaptive Immunity
Preperation	The product should be stored undiluted at 4C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µ g of the protein.
Formulation	Phosphate-buffered aqueous solution, ph7.2.
References	Tesselaar, K., Gravestein, L. A., Van Schijndel, G. M., Borst, J., & Van Lier, R. A. (1997). Characterization of murine CD70, the ligand of the TNF receptor family member CD27. The Journal of Immunology, 159(10), 4959-4965. Oshima, H., Nakano, H., Nohara, C., Kobata, T., Nakajima, A., Jenkins, N. A., ... & Okumura, K. (1998). Characterization of murine CD70 by molecular cloning and mAb. International immunology, 10(4), 517-526. Bullock, T. N., & Yagita, H. (2005). Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells. The Journal of Immunology, 174(2), 710-717.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 500 ug

Listprice: €369.00

Price: €369.00

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Delivery expected until 9/11/2025

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