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Anti-Human TIM3 APC 25 tests

Anti-Human TIM3 APC 25 tests

€173.00

Excl. VAT

Item no.	78211-80-25
Manufacturer	BioGems
Amount	25 tests
Category	Oncology Neuroscience Aging & Neurological Disorders Antibodies Flow Cytometry Primary Antibodies By Organ Head & Neck Cancer
Type	Antibody
Format	APC
Applications	FC
Clone	F38-2E2
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 kappa
Conjugate/Tag	APC
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Description	The F38-2E2 monoclonal antibody specifically reacts with human T cell immunoglobulin and mucin domain containing protein (TIM3), a transmembrane molecule found on monocytes, macrophages, dendritic cells, and activated T cell types such as Treg, Th1, and Th17. TIM3 can exist in soluble and membrane bound forms and the relevant ligand for the protein is Galectin-9. It plays a role in the creation of immunological tolerances, the secretion of Th1 and Th17 related cytokines, and HIV infection.
Research Interest	Adaptive Immunity
Preperation	The product should be stored undiluted at 4C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Formulation	Phosphate-buffered aqueous solution, ≤ 0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
References	Klibi, J., Niki, T., Riedel, A., Pioche-Durieu, C., Souquere, S., Rubinstein, E., ... & Busson, P. (2009). Blood diffusion and Th1-suppressive effects of galectin-9-"containing exosomes released by Epstein-Barr virus-"infected nasopharyngeal carcinoma cells. Blood, 113(9), 1957-1966. Hastings, W. D., Anderson, D. E., Kassam, N., Koguchi, K., Greenfield, E. A., Kent, S. C., ... & Kuchroo, V. K. (2009). TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. European journal of immunology, 39(9), 2492-2501. Koguchi, K., Anderson, D. E., Yang, L., O'Connor, K. C., Kuchroo, V. K., & Hafler, D. A. (2006). Dysregulated T cell expression of TIM3 in multiple sclerosis. The Journal of experimental medicine, 203(6), 1413-1418.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 25 tests

Listprice: €173.00

Price: €173.00

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Delivery expected until 8/28/2025

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