SASRIN resin (200-400 mesh, 0.80-1.20 mmol/g)

SASRIN (=Super Acid Sensitive ResIN) was developed in our own laboratories especially for Fmoc solid phase synthesis (EP 0 292 729, US 4, 831, 084 and US 4, 914, 151). Its high acid lability enables the cleavage and isolation of the protected peptide fragment. Beside SPPS SASRIN has been used in several organic reactions like the synthesis of 4-aryl substituted beta-lactams employing Suzuki and Heck couplings, the synthesis of beta-sultams, quinazoline-2, 4-diones, pyridines and pyrido[2, 3-d]pyrimidines and the generation of secondary alkylamines by borane reduction. S.S.Rahman et al. reported on the FT-IR and Raman spectroscopic monitoring of reactions on a single SASRIN bead and C.L.Brummel et al. on the evaluation of mass spectrometric methods applicable to the direct analysis of non-peptide bead-bound combinatorial libraries. For a review on the manifold applications of our SASRIN resin, including many useful procedures, please ask for our SASRIN brochure. Bachem offers a large variety of Fmoc-amino acids linked to SASRIN resin. See also D-2440.