Comparison

UIMC1 Antibody - middle region (ARP75597_P050)

Item no. ARP75597_P050
Manufacturer AVIVA Systems Biology
Amount 100 ul
Category
Type Antibody Polyclonal
Format Lyophilized powder
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Alias UIMC1,RAP80, RXRIP110
Available
Gene symbol
UIMC1
Protein size
641
Molecular weight
70kDa
Product format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Gene id
51720
Reconstitution and storage
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Partner proteins
HIST2H2AC. UBC. FANCG. RPS6. HSPA4. CDK1. C1QBP. BRCA1. FAM175A. BRCC3. ELC1. ELA1. BLM. SKIL. SUMO1. SUMO2. MDC1. PAXIP1. Cep57. BRE. HIST2H2BE. ESR1. ATP8A2. KIAA0368. RBBP8. RAD23A. BABAM1. TP53. MDM2. SSU72. FAM175B. ERP44. G3BP1. G3BP2. SPATA2. BAG5.
Description of target
UIMC1 is a ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. It plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. It also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. It may interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. And it may indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
Purification
Affinity purified
Clonality
Polyclonal
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Human UIMC1
Drywet
Wet Ice

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ul
Available: In stock
available

Delivery expected until 7/31/2025 

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