Anti-SMAD2 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q15796

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ' mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

SMAD2

A synthetic peptide of human SMAD2.

Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.

Calculated: 48kDa/52kDa.

Anti-Mothers Against Decapentaplegic Homolog 2 antibody
Anti-Mad Homolog 2 antibody
Anti-Mothers Against Dpp Homolog 2 antibody
Anti-Jv18-1 antibody
Anti-Mad-Related Protein 2 antibody
Anti-Hmad-2 antibody
Anti-Smad Family Member 2 antibody
Anti-Smad 2 antibody
Anti-Smad2 antibody
Anti-Hsmad2 antibody
Anti-SMAD2 MADH2 MADR2 antibody

FOR RESEARCH USE ONLY (RUO).