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CD3 Antibody [G4.18]

CD3 Antibody [G4.18]

€749.00

Excl. VAT

Item no.	PRS-76-235-0.5mg
Manufacturer	ProSci
Amount	0.5 mg
Category	Antibodies Flow Cytometry Immunohistochemistry Primary Antibodies
Type	Antibody Monoclonal
Format	liquid
Applications	FC, IHC
Specific against	Rat (Rattus norvegicus)
Host	Mouse
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Cd3d, Cd3d
Available
Shipping	blue ice or RT
By Research Area	Immunology, Functional Assays
Specificity	The G4.18 monoclonal antibody specifically reacts with rat CD3, a T cell lineage marker and associated with the T cell receptor (TCR).
Purification	The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Clonality	Monoclonal
Clone	G4.18
Isotype	Mouse IgG3, kappa
Conjugate	Unconjugated
Buffer	Phosphate-buffered aqueous solution, ph7.2.
Concentration	batch dependent
Storage Conditions	The product should be stored undiluted at 4˚ C . Do not freeze.
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
Modifications	None
Ncbi Official Symbol	Cd3d
Ncbi Gene Id #	25710
User Note	Optimal dilutions for each application to be determined by the researcher.
Ncbi Official Symbol	Cd3d
Ncbi Official Full Name	CD3 molecule, delta
Ncbi Organism	Rattus norvegicus
Swissprot #	P19377
Background	The G4.18 monoclonal antibody specifically reacts with rat CD3, a T cell lineage marker and associated with the T cell receptor (TCR). CD3 is involved in antigen recognition, cell activation, and signal transduction and is found on subsets of NK-T, peripheral T, dendritic epidermal T, and thymocyte cells. Immobilized G4.18 antibody activates T cells in vitro and in vivo treatments of the G4.18 antibody prevents cardiac and skin allograft rejection.
Background References 1	Nicolls, M. R., Aversa, G. G., Pearce, N. W., Spinelli, A., Berger, M. F., Gurley, K. E., Hall, B. M. (1993). Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody.Transplantation, 55(3), 459-468.
Background References 2	Morris, D. L., Komocsar, W. J. (1997). Immunophenotyping analysis of peripheral blood, splenic, and thymic lymphocytes in male and female rats.Journal of pharmacological and toxicological methods, 37(1), 37-46.
Background References 3	Tran, G. T., Carter, N., He, X. Y., Spicer, T. S., Plain, K. M., Nicolls, M., ... Hodgkinson, S. J. (2001). Reversal of experimental allergic encephalomyelitis with non-mitogenic, non-depleting anti-CD3 mAb therapy with a preferential effect on Th1 cells that is augmented by IL-4.International immunology, 13(9), 1109-1120.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.5 mg

Listprice: €749.00

Price: €749.00

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Delivery expected until 10/2/2025

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