SYPL1 Antibody

Neuroscience

SYPL1 antibody can be used for detection of SYPL1 by Western blot at 1 μ g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Cat. No. 1303 - Human Brain Tissue Lysate

Polyclonal

Unconjugated

1 mg/mL

Cat. No. 5285P – SYPL1 Peptide

None

NP_006745

6856

SYPL1

Homo sapiens

SYPL1 Antibody: The synaptophysin-like protein 1, also known as pantophysin, is a homolog of the neuroendocrine-specific protein synaptophysin, with the highest level of homology across its four transmembrane domains. Unlike synaptophysin however, SYPL1 is ubiquitously expressed and found in small cytoplasmic transport vesicles regardless of their content. SYPL1 is thought to play a multifunctional role in vesicle biogenesis and transport and is a component of adipocyte transport vesicles, and thus may be involved in adipocyte secretion. SYPL1 also interacts with vesicle-associated membrane protein 2 (VAMP-2) in adipocytes and associates with GLUT4-containing vesicles.

Brooks CC, Scherer PE, Cleveland K, et al. Pantophysin is a phosphoprotein component of adipocyte transport vesicles and associates with GLUT4-containin vesicles. J. Biol. Chem.2000; 275:2029-36.

Western blot analysis of SYPL1 in human brain tissue lysate with SYPL1 antibody at 1 μ g/mL in (A) the absence and (B) the presence of blocking peptide.