CD40 Antibody [FGK45]

blue ice or RT

Recombinant mouse CD40 fusion protein.

Recognizes mouse CD40.

Monoclonal

IgG2a

Liquid. In PBS containing 0.02% sodium azide.

Stable for at least 1 year after receipt when stored at -20˚ C.

None

172046819

21939

Cd40

Mus musculus

CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.