Anti-Mouse CD152 (CTLA-4) - DyLight 550

Antibody Details

Product Details

Reactivity Species

Mouse

Host Species

Syrian Hamster

Immunogen

Purified Recombinant Mouse CTLA-4 (> 98%)

Product Concentration

0.2 mg/ml

Formulation

This DyLight® 550 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.

Storage and Handling

This DyLight^® 550 conjugate is stable when stored at 2-8°C. Do not freeze.

Country of Origin

USA

Shipping

Next Day 2-8°C

Excitation Laser

Yellow Laser (563 nm)

RRID

AB_2828814

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

Clone 9H10 recognizes an epitope on mouse CTLA-4.

Antigen Distribution

CTLA-4 is expressed on activated T and B lymphocytes.

Background

CTLA-4 is a 33 kD member of the Ig superfamily similar to CD28 in amino acid sequence, structure, and genomic organization. CTLA-4 is a protein receptor that functions as an immune checkpoint and downregulates immune responses. It is involved in the development of protective immunity and thymocyte regulation, in addition to the induction and maintenance of immunological tolerance. CTLA-4 has therapeutic potential both as an agonist to reduce immune activity, and an antagonist to increase immune activity.

Antigen Details

Protein

CTLA-4

Ligand/Receptor

CD80 (B7-1), CD86 (B7-2)

PubMed

CTLA-4

NCBI Gene Bank ID

12477

UniProt.org

Information on Uniprot.org

Research Area

Immunology

Technical Protocols