Neurotrophin-3 IHC Antibody

Description Neurotrophin-3 (NT-3) is a member of a family of neurotrophic factors that is closely related to both nerve growth factor and brain derived neurotrophic factor. These proteins are involved in the maintenance of the adult nervous system and affect development of neurons in the embryo when it is expressed in human placenta. NT3 deficient mice generated by gene targeting display severe movement defects of the limbs. Catalog Number IW-PA1062 Quantity 9 ml Host Rabbit Clone Polyclonal Isotype IgG Immunogen A synthetic peptide mapping at the middle region of human neurotrophin-3, identical to the related rat and mouse sequence. Purity Immunogen affinity purified Conjugate Unconjugated Species Reactivity Human, mouse, rat.Not tested in other species. Positive Control Brain Cellular Localization Cytoplasmic Form Ready to use solution in PBS with stabilizer and 0.01% sodium azide. No further dilution needed. Serum blocking step should be omitted. Storage Store at 2-8 CC. Do not freeze. Applications IHC-P: Heat induced epitope retrieval improve stain on formalin fixed paraffin sections. IHC-Fr: Not tested. ICC: Not tested. Limitations This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user. Precautions Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes. References 1. Jones, K. R.; Reichardt, L. F. : Molecular cloning of a human gene that is a member of the nerve growth factor family. Proc. Nat. Acad. Sci. 87: 8060-8064, 1990. 2. Rosenthal A., Goeddel D.V., Nguyen T., Lewis M., Shih A., Laramee G.R., Nikolics K., Winslow J.W.; "Primary structure and biological activity of a novel human neurotrophic factor."; Neuron 4:767-773(1990).