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Anti-Mouse IFN beta In Vivo Antibody - Ultra Low Endotoxin (HDB-4A7)

Anti-Mouse IFN beta In Vivo Antibody - Ultra Low Endotoxin (HDB-4A7)

Item no.	ICH1110UL-5MG
Manufacturer	IchorBio
Amount	5mg
Category	Antibodies In Vivo Antibodies Western Blot Blocking
Type	Antibody
Purity	>98% by SDS-PAGE and HPLC
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	IFN-b, IFN-beta, Type-1 interferon, Interferon beta
Available
Specificity	Anti-IFN beta In Vivo Antibody - Ultra Low Endotoxin (HDB-4A7) recognizes an epitope on Mouse IFN-beta and binds specifically to murine IFNbeta and does not bind murine IFNg or several different IFNa species (a-1,4,5 or 13); HDb-4A7 binds both recombinant
Manufacturers Product Category	Ultra-Low Endotoxin, anti-mouse
Target Information	IFN beta
Isotype Information	Mouse IgG2a
Purification method	This antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Immunogen	Plasmid DNA encoding murine IFNb
Concentration	1.0 - 5.0 mg/ml
Formulation	0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
Endotoxin	≤ 0.5 EU/mg as determined by the LAL method
Aggregation	Aggregation level ≤ 1%
IMPACT Pathogen Test	We use the IMPACT test generated by IDEXX Laboratories to guarantee our Ultra Low Endotoxin antibodies are pathogen free. Our mouse antibodies are tested for: - Mycoplasma spp. - Mycoplasma pulmonis - Sendai virus - Mouse hepatitis virus - Pneumonia virus of mice - Minute virus of mice - Mouse parvovirus (MPV1-5) - Theiler's murine encephalomyelitis virus - Murine norovirus - Reovirus 3 - Mouse rotavirus - Ectromelia virus - Lymphocytic choriomeningitis virus - Polyoma virus - Lactate dehydrogenase-elevating virus - Mouse adenovirus (MAD1, MAD2) - Mouse cytomegalovirus - K virus - Mouse thymic virus - Hantaan virus - Corynebacterium bovis - Corynebacterium spp. (HAC2)
Storage	anti-IFN beta In Vivo Antibody - Ultra Low Endotoxin (HDB-4A7) is stable when stored at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
Application Notes	Functional Assay: In Vitro Activity of HDB-4A7 - inhibits IFNb-induced Stat1 phosphorylation (level of inhibition is similar to that seen using anti-IFNAR1 mAb (MAR1-5A3). - blocks IFNb induction of MHC-I expression (H2-Kb) using L929 or fibrosarcoma cell lines. - neutralizes IFNb-induced antiviral activity in vitro following infection of L929 cells with VSV In Vivo Activity of HDB-4A7 - circulates with a half-life of ~ 14 days. - blocks in vivo IFNb leading to increased the lethality of mice infected with West Nile Virus (WNV), similar to susceptibility of IFNb-/- mice. - Each investigator should determine their own optimal working dilution for specific applications.
Use	Products are for research use only. Not for use in diagnostic or therapeutic procedures.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 5mg

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Delivery expected until 8/7/2025

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