CTLA4 Antibody

Human

Synthetic peptide corresponding to residues near the C terminal of human Cytotoxic T-lymphocyte protein 4

ELISA:1:2000-1:10000

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

Antigen Affinity Purified

Immunology, Stem cells