CD3G polyclonal antibody

P09693(Human) P11942(Mouse)

The T cell antigen receptor (TCR) recognizes foreign antigens and translates such recognition events into intracellular signals that elicit a change in the cell from a dormant to an activated state. Much of this signaling process can be attributed to a multisubunit complex of proteins that associates directly with the TCR. This complex has been designated CD3 (cluster of differentiation 3). It is composed of five invariant polypeptide chains that associate to form three dimers: a heterodimer of gamma and epsilon chains (gammaepsilon), a heterodimer of delta and epsilon chains (deltaepsilon) and a homodimer of two zeta chains (zetazeta) or a heterodimer of zeta and eta chains (zetaeta). The zeta and eta chains are encoded by the same gene but differ in their carboxyl-terminal ends due to an alternative splicing event. The gamma, epsilon and delta chains each contain a single copy of a conserved immunoreceptor tyrosine-based activation motif (ITAM).

ProA affinity purified

CD3G polyclonal antibody detects endogenous levels of CD3G protein.

For research use only, not for use in diagnostic procedure.