mAb anti-Human p383-ELK-1

Serine383 phosphorylated human ETS-like transcription factor 1 (p383 ELK-1)

Reactive to the un-conjugated serine383 phosphorylated human ELK-1 peptide fragment, and reactive to the serine383 phosphorylated human ELK-1 peptide fragment conjugated to KLH or the peptide- BSA conjugate. Not reactive to KLH or BSA.

Sp2/0-Ag14

ELK1 belongs to the EST transcription factor family. Proteins in the family have a unique DNA binding domain that binds to conserved DNA sequences. Phosphorylation of ELK1 at serine 383 and 389 by mitogen-activated protein kinases (MAPKs) activates ELK1. The binding of ELK1 to target sequences is also regulated by its co-factor, serum response factor (SRF), by alternative splicing, and by SUMOylation. ELK1 regulates the transcription of c-fos and genes encoding cytoskeleton proteins, and was found to play a role in long-term memory formation, drug addiction and other neurological disorders.

Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.

Store at -20oC