MME/CD10 Antibody

Synthetic Peptide

This gene encodes a common acute lymphocytic leukemia
antigen that is an important cell surface marker in the diagnosis
of human acute lymphocytic leukemia (ALL). This protein is present
on leukemic cells of pre-B phenotype, which represent 85% of cases
of ALL. This protein is not restricted to leukemic cells, however,
and is found on a variety of normal tissues. It is a glycoprotein
that is particularly abundant in kidney, where it is present on the
brush border of proximal tubules and on glomerular epithelium. The
protein is a neutral endopeptidase that cleaves peptides at the
amino side of hydrophobic residues and inactivates several peptide
hormones including glucagon, enkephalins, substance P, neurotensin,
oxytocin, and bradykinin. This gene, which encodes a 100-kD type II
transmembrane glycoprotein, exists in a single copy of greater than
45 kb. The 5' untranslated region of this gene is alternatively
spliced, resulting in four separate mRNA transcripts. The coding
region is not affected by alternative splicing. [provided by
RefSeq].

Monoclonal

4311

Mouse Monoclonal Antibody (Mab)

Immunohistochemical analysis of paraffin-embedded Human tonsil section using Pink1(Cat#AM1949b). AM1949b was diluted at 1:1000 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.

1:1000

WB

NP_000893.2

85514

HUMAN

NP_000893.2; NP_009218.2; NP_009219.2; NP_009220.2