Mouse Monoclonal Antibody to CD10

Catalog Number: sAP-0870
Product Name: Mouse Monoclonal Antibody to CD10
Target Molecle: CD10
Aliases: MME; NEP; SFE; CALLA
Species: Human;
MW: 85.5kDa
Enterez GeneID: 4311
General Information: This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. ;
Immunogen: Purified recombinant fragment of human CD10 (AA: 52-246) expressed in E. Coli.
Clone: MM7D4B1;
Isotype: Mouse IgG1
Size and Concentration: 100ug/1mg/ml
Supplied As: Lyophilized Powder from 100ul of Purified antibody in PBS with 0.05% sodium azide
Reconstitution and Storage: Reconstitued with 100ul sterile DI H2O, at stored at 4C or -20C for short or long term storage.
Applications: ELISA: 1 to 10000; WB: 1 to 500 - 1 to 2000; IHC: 1 to 200 - 1 to 1000
References: 1. Diabetes. 2012 Mar; 61(3):574-85. ; 2. Biochim Biophys Acta. 2011 Dec; 1811(12):1194-200. ;