ATN-161

ATN-161 is a novel small peptide inhibitor of integrin alpha5beta1; a beta integrin antagonist with antitumor activity. ATN-161 inhibited VEGF-induced migration and capillary tube formation in hCECs. In vivo, injection of ATN-161 after laser photocoagulation inhibited CNV leakage and neovascularization to an extent similar to AF564. Furthermore, SD-OCT and histologic examinations indicated that ATN-161 significantly decreased the size of laser-induced lesions. Treatment with the alpha5beta1 signaling inhibitor ATN-161 significantly blunts atherosclerotic plaque development in apolipoprotein E-deficient mice, characterized by reduced vascular cell adhesion molecule-1 expression and macrophage accumulation without affecting fibrous cap size.

597, 64

DMSO