« Back
Home /
LY-411575

LY-411575

€120.00

Excl. VAT

Item no.	M2130-10mg
Manufacturer	AbMole
Amount	10mg
Category	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Head & Neck Cancer Gastric Cancer
Type	Inhibitors
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	LSN-411575
Similar products	LY-411575, LSN-411575
Available
Cas #	209984-57-6
Bioactivity information	LY-411575 is a selective, cell permeable gamma-secretase inhibitor with IC50 of 0.082 nM for cell-based gamma-secretase. LY-411575 decreased overall thymic cellularity and impaired intrathymic differentiation at the CD4(-)CD8(-)CD44(+)CD25(+) precursor stage. LY-411575 reduces Abeta/42 after acute or chronic treatment, and blocks Notch activation. Treatment with LY-411575 (LSN-411575) arrests KrasG12V-driven NSCLCs in association with inhibition of HES1 expression and ERK phosphorylation.
Target	Gamma-secretase
Synonyms	LSN-411575
MW	479, 48
Formula	C26H23F2N3O4
Solubility	DMSO 60 mg/mL
Purity	0, 9915

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

Request product datasheet

M2130-10mg-safety-datasheet.pdf