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NSC 74859

NSC 74859

€150.00

Excl. VAT

Item no.	M1782-50mg
Manufacturer	AbMole
Amount	50mg
Category	Oncology Neuroscience Neural Lineage Markers Neural Transcription Factors Inhibitors & Compound Libraries Small Molecules By Organ Hepatic Cancer
Type	Inhibitors
Specific against	other
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	S3I-201
Similar products	NSC 74859, S3I-201
Available
Cas #	501919-59-1
Bioactivity information	NSC 74859 (S31-201) is a STAT3 inhibitor and is effective in hepatocellular cancers with disrupted TGF-beta signaling.Both CD133 (+) Huh-7 cells and CD133 (-) Huh-7 cells are equally sensitive to NSC 74859 treatment and STAT3 inhibition, with an IC (50) of 100 muM.Furthermore, NSC 74859 (S31-201) treatment of Huh-7 xenografts in nude mice significantly retarded tumor growth, with an effective dose of only 5 mg/kg. Moreover, NSC 74859 (S31-201) inhibited tyrosine phosphorylation of STAT3 in HCC cells in vivo.
Target	STAT
Synonyms	S3I-201
MW	365, 36
Formula	C16H15NO7S
Solubility	DMSO
Purity	>98%

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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M1782-50mg-safety-datasheet.pdf