Human Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) ELISA Kit

Human Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) ELISA Kit is a sandwich ELISA kit for use with Tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of BLys-63-Specific Deubiquitinase BRCC36 (BRCC3)
No significant cross-reactivity or interference between Lys-63-Specific Deubiquitinase BRCC36 (BRCC3) and analogues was observed.

Please note that this kit is also available as a CLIA Kit abx496096. This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.

P46736

BRCC3

300617

< 0.07 ng/ml

Sandwich

Tissue homogenates and other biological fluids.

This product is for research use only.

The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.

Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.