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PerCP-Cyanine5.5 Anti-Mouse CD4 (GK1.5)

PerCP-Cyanine5.5 Anti-Mouse CD4 (GK1.5)

66,00 €

Zzgl. MwSt.

ArtNr	65-0041-U025
Hersteller	Tonbo Biosciences
Menge	25 ug
Kategorie	Oncology Neuroscience Aging & Neurological Disorders Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Flow Cytometry Primary Antibodies By Organ Heart & Blood Cancer
Typ	Antibody Monoclonal
Format	PerCP-Cy5.5
Applikationen	FC
Clon	GK1.5
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG2b kappa
Konjugat/Tag	PerCP/Cy5.5
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	L3T4, T4
Similar products	GK1.5
Lieferbar
Description	The GK1.5 antibody reacts with mouse CD4, a 55 kDa protein which acts as a co-receptor for the T cell receptor (TCR) in its interaction with MHC Class II molecules on antigen-presenting cells. The extracellular domain of CD4 binds to the beta-2 domain of MHC Class II, while its cytoplasmic tail provides a binding site for the tyrosine kinase lck, facilitating the signaling cascade that initiates T cell activation. CD4 is typically expressed on thymocytes, certain mature T cell populations such as Th17 and T regulatory (Treg) cells, as well as on dendritic cells. The GK1.5 antibody is widely used as a phenotypic marker for CD4 expression. If used together, the GK1.5 antibody and an alternative antibody, Anti-Mouse CD4 clone RM4-5, will " compete" for binding, i.e. RM4-5 is able to block GK1.5 binding to cells. In contrast, the Anti-Mouse CD4 clone RM4-4 does not block binding of the GK1.5 antibody to cells (Arora S et al. 2006. Infect. Immun. 74: 4339-4348). The GK1.5 antibody is also reported to be cross-reactive with Syrian hamster CD4.
Alternative Names	L3T4, T4
Gene ID	12504
Citations	Taniguchi RT, DeVoss JJ, Moon JJ, Sidney J, Sette A, Jenkins MK, and Anderson MS. 2012. Proc. Natl. Acad. Sci. 109: 7847-7852. (in vivo depletion) Wolkers MC, Gerlach, C, Arens R, Janssen EM, Fitzgerald P, Schumacher TN, Medema JP, Green DR, and Schoenberger SP. 2012. Blood. 119:798-804. (in vivo depletion) Lee L-F, Logronio K, Tu GH, Zhai W, Ni I, Mei L, Dilley J, Yu J, et al. 2012. Proc. Natl. Acad. Sci. 10.1073. (Flow cytometry). Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, and Krummel MF. 2012. J. Exp. Med. 10:1084. (Immunohistochemistry - OCT embedded frozen tissue) Stephen TL, Wilson BS, and Laufer TM. 2012. Proc. Natl. Acad. Sci. 109: 7415-7420. (Immunoprecipitation) Hammerbeck CD and Hooper JW. 2011. J. Virol. 85(19) 9929-9944. (Flow cytometry - Syrian hamster). Diamond MS, Kinder M, Matsushita H, Mashayekhi M, Dunn GP, Archambault JM, Lee H, Arthur CD, White JM, Kalinke U, Murphy KM, and Schreiber RD. 2011. J. Exp. Med. 208: 1989-2003. (in vitro blocking) Kao H, Lin J, Littman DR, Shaw AS, and Allen PM. 2008. J. Immunol. 181: 8248-8257. (Immunoprecipitation) Felix NJ, Donermeyer DL, Horvath S, Walters JJ, Gross M, suri A, and Allen PM. 2007. Nat. Immunol. 8:388-397. (in vitro blocking)
Cross Reactivity	Syrian Hamster

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Menge: 25 ug

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Preis: 66,00 €

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