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Anti-Lamin A/C antibody

Anti-Lamin A/C antibody

89,00 €

Zzgl. MwSt.

ArtNr	STJ99233-50
Hersteller	St John's Laboratory
Menge	50ul
Kategorie	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Carcinoma Sarcoma Cell Biology Cytoskeleton Western Blot Immunofluorescence Primary Antibodies Intermediate filaments By Organ Breast Cancer
Typ	Antibody Monoclonal
Applikationen	WB, IF
Clon	5D12-C6-E9
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Prelamin-A/C </br> Lamin-A/C </br> 70 kDa lamin </br> Renal carcinoma antigen NY-REN-32
Similar products	Prelamin-A/C Lamin-A/C 70 kDa lamin Renal carcinoma antigen NY-REN-32
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Clonality	Monoclonal
Conjugation	Unconjugated
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Uniprot ID	P02545
Storage	Store at-20° C, and avoid repeat freeze-thaw cycles.
Concentration	1 mg/ml
Description	Mouse monoclonal to Lamin A/C.
Gene ID	4000
Gene symbol	LMNA
Immunogen	Purified recombinant human LMNA protein fragments expressed in E.coli.
Short Description	Mouse monoclonal against Lamin A/C
Tissue specificity	In the arteries, prelamin-A/C accumulation is not observed in young healthy vessels but is prevalent in medial vascular smooth muscle cells (VSMCs) from aged individuals and in atherosclerotic lesions, where it often colocalizes with senescent and degenerate VSMCs. Prelamin-A/C expression increases with age and disease. In normal aging, the accumulation of prelamin-A/C is caused in part by the down-regulation of ZMPSTE24/FACE1 in response to oxidative stress.
Cellular localization	Nucleus. Nucleus envelope. Nucleus lamina. Nucleus, nucleoplasm. Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then be inserted into the nuclear lamina. EMD is required for proper localization of non-farnesylated prelamin-A/C.. Isoform C: Nucleus speckle
Molecular weight	74/63kDa
Dilution range	WB 1:1000 ICC 1:200
Alternative names	Prelamin-A/C Lamin-A/C 70 kDa lamin Renal carcinoma antigen NY-REN-32
Protein name	Prelamin-A/C Lamin-A/C 70 kDa lamin Renal carcinoma antigen NY-REN-32
Note	FOR RESEARCH USE ONLY (RUO).
Swiss port key	P02545_HUMAN

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Menge: 50ul

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Preis: 89,00 €

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