Anti-TLR2 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

O60603

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants.

TLR2

Rabbit polyclonal against TLR2

Membrane
Single-Pass Type I Membrane Protein
Cytoplasmic Vesicle
Phagosome Membrane
Membrane Raft
Does Not Reside In Lipid Rafts Before Stimulation But Accumulates Increasingly In The Raft Upon The Presence Of The Microbial Ligand
In Response To Diacylated Lipoproteins
Tlr2:Tlr6 Heterodimers Are Recruited In Lipid Rafts
This Recruitment Determines The Intracellular Targeting To The Golgi Apparatus
Triacylated Lipoproteins Induce The Same Mechanism For Tlr2:Tlr1 Heterodimers

WB 1:500-1:2000

Toll-Like Receptor 2
Toll/Interleukin-1 Receptor-Like Protein 4
Cd Antigen Cd282

TLR2_HUMAN