Anti-CLU antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P10909

The protein encoded by this gene is a secreted chaperone that can under some stress conditions also be found in the cell cytosol. It has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. Alternate splicing results in both coding and non-coding variants.

CLU

Rabbit polyclonal against CLU

Isoform 1: Secreted
Can Retrotranslocate From The Secretory Compartments To The Cytosol Upon Cellular Stress
Isoform 4: Cytoplasm
Keeps Cytoplasmic Localization In Stressed And Unstressed Cell
Isoform 6: Cytoplasm
Nucleus
Cytoplasm
Mitochondrion Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cytosol
Microsome
Endoplasmic Reticulum
Mitochondrion
Perinuclear Region
Cytoplasmic Vesicle
Secretory Vesicle
Chromaffin Granule
Secreted Isoforms Can Retrotranslocate From The Secretory Compartments To The Cytosol Upon Cellular Stress
Detected In Perinuclear Foci That May Be Aggresomes Containing Misfolded
Ubiquitinated Proteins
Detected At The Mitochondrion Membrane Upon Induction Of Apoptosis
Under Er Stress
A Immaturely Glycosylated Pre-Secreted Form Retrotranslocates From The Endoplasmic Reticulum (Er)-Golgi Network To The Cytoplasm To Localize In The Mitochondria Through Hspa5 Interaction
Er Stress Reduces Secretion
Under The Stress
Minor Amounts Of Non-Secreted Forms Accumulate In Cytoplasm
Non-Secreted Forms Emerge Mainly From Failed Translocation
Alternative Splicing Or Non-Canonical Initiation Start Codon

IF 1:50-1:200

Clusterin
Aging-Associated Gene 4 Protein
Apolipoprotein J
Apo-J
Complement Cytolysis Inhibitor
Cli
Complement-Associated Protein Sp-40-40
Ku70-Binding Protein 1
Na1/Na2
Sulfated Glycoprotein 2
Sgp-2
Testosterone-Repressed Prostate Message 2
Trpm-2 Cleaved Into-Clusterin Beta Chain
Apojalpha
Complement Cytolysis Inhibitor A Chain-Clusterin Alpha Chain
Apojbeta
Complement Cytolysis Inhibitor B Chain

CLUS_HUMAN