Anti-Caspase-1 antibody

Unconjugated

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Store at-20° C, and avoid repeat freeze-thaw cycles.

Caspase-1 is a protein encoded by the CASP1 gene which is approximately 45, 1 kDa. Caspase-1 is localised to the cytoplasm. It is involved in amyotrophic lateral sclerosis, toll-like receptor signalling pathways, p53 signalling and the TNFR1 pathway. This protein falls under the the cysteine-aspartic acid protease family. upon activation It plays a central role in the execution-phase of cell apoptosis. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules. Caspase-1 is expressed mainly in the spleen and lung. Mutations in the CASP1 gene may result in shigellosis and cowpox. STJ98574 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Caspase-1.

CASP1

Internal

Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.

IF 1:50-200
WB 1:500-2000
IHC 1:50-300
ELISA 1:10000-20000

Caspase-1
CASP-1
Interleukin-1 beta convertase
IL-1BC
Interleukin-1 beta-converting enzyme
ICE
IL-1 beta-converting enzyme
p45
Caspase-1 subunit p20
Caspase-1 subunit p10

P29466_HUMAN