Anti-Casp8 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q14790

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.

CASP8

Rabbit polyclonal against Casp8

Cytoplasm

WB 1:500-1:2000

Caspase-8
Casp-8
Apoptotic Cysteine Protease
Apoptotic Protease Mch-5
Cap4
Fadd-Homologous Ice/Ced-3-Like Protease
Fadd-Like Ice
Flice
Ice-Like Apoptotic Protease 5
Mort1-Associated Ced-3 Homolog
Mach Cleaved Into-Caspase-8 Subunit P18-Caspase-8 Subunit P10

CASP8_HUMAN