Anti-DDX1 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Q92499

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin.

DDX1

Rabbit polyclonal against DDX1

Nucleus
Cytoplasm
Cytoplasmic Granule
Cytosol
Mitochondrion
Localized With Mbnl1
Tial1 And Ybx1 In Stress Granules Upon Stress
Localized With Cstf2 In Cleavage Bodies
Forms Large Aggregates Called Ddx1 Bodies
Relocalized Into Multiple Foci (Ir-Induced Foci Or Irif) After Ir Treatment
A Process That Depends On The Presence Of Chromosomal Dna And/Or Rna-Dna Duplexes
Relocalized At Sites Of Dna Double-Strand Breaks (Dsbs) In An Atm-Dependent Manner After Ir Treatment
Colocalized With Rela In The Nucleus Upon Tnf-Alpha Induction
Enters Into The Nucleus In Case Of Active Transcription While It Accumulates In Cytosol When Transcription Level Is Low
Colocalizes In The Cytosol With Ddx21
Dhx36 And Ticam1
Colocalizes In The Mitochondria With Ticam1 And Poly(I:c) Rna Ligand
The Multi-Helicase-Ticam1 Complex May Translocate To The Mitochondria Upon Poly(I:c) Stimulation
(Microbial Infection) Relocalized To The Cytoplasm With A Perinuclear Staining Pattern In Avian Infectious Bronchitis Virus (Ibv)-Infected Cells
Required For Proper Localization Of Hiv-1 Rev

WB 1:500-1:2000 IHC 1:50-1:200 IF 1:10-1:100 IP 1:20-1:50

Atp-Dependent Rna Helicase Ddx1
Dead Box Protein 1
Dead Box Protein Retinoblastoma
Dbp-Rb

DDX1_HUMAN