Anti-HDAC3 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

O15379

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.

HDAC3

Rabbit polyclonal against HDAC3

Nucleus
Cytoplasm
Cytosol
Colocalizes With Xbp1 And Akt1 In The Cytoplasm
Predominantly Expressed In The Nucleus In The Presence Of Ccar2

WB 1:500-1:2000 IHC 1:50-1:100 IF 1:50-1:200 IP 1:50-1:200 ChIP 1:20-1:100

Histone Deacetylase 3
Hd3
Rpd3-2
Smap45

HDAC3_HUMAN