Anti-CASP1 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P29466

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.

CASP1

Rabbit polyclonal against CASP1

Cytoplasm
Cell Membrane

WB 1:500-1:2000

Caspase-1
Casp-1
Interleukin-1 Beta Convertase
Il-1bc
Interleukin-1 Beta-Converting Enzyme
Ice
Il-1 Beta-Converting Enzyme
P45 Cleaved Into-Caspase-1 Subunit P20-Caspase-1 Subunit P10

CASP1_HUMAN