Anti-LRP6 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

O75581

This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP-(regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.

LRP6

Rabbit polyclonal against LRP6

Cell Membrane
Single-Pass Type I Membrane Protein
Endoplasmic Reticulum
Membrane Raft
On Wnt Signaling
Undergoes A Cycle Of Caveolin-Or Clathrin-Mediated Endocytosis And Plasma Membrane Location
Released From The Endoplasmic Reticulum On Palmitoylation
Mono-Ubiquitination Retains It In The Endoplasmic Reticulum In The Absence Of Palmitoylation
Phosphorylated
Aggregates And Colocalizes With Axin1 And Gsk3b At The Plasma Membrane In Lrp6-Signalsomes
Chaperoned To The Plasma Membrane By Mesd

WB 1:500-1:2000 IHC 1:50-1:200

Low-Density Lipoprotein Receptor-Related Protein 6
Lrp-6

LRP6_HUMAN