Anti-GPX4 antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P36969

The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.

GPX4

Rabbit polyclonal against GPX4

Isoform Mitochondrial: Mitochondrion
Isoform Cytoplasmic: Cytoplasm

WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200

Phospholipid Hydroperoxide Glutathione Peroxidase
Phgpx
Glutathione Peroxidase 4
Gpx-4
Gshpx-4

GPX4_HUMAN