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Follicle-stimulating hormone (FSH)

Follicle-stimulating hormone (FSH)

4.545,00 €

Zzgl. MwSt.

ArtNr	THP-0145
Hersteller	Creative BioMart
Menge	1ea
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins
Specific against	Hu
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	97048-13-0
Similar products	97048-13-0
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Description	The product is a purified form of follicle-stimulating hormone (FSH) that is manufactured by extraction from human urine and then purified. It consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 while the beta subunit is glycosylated at Asn 7 and Asn 24. The product is important in the development of follicles produced by the ovaries.
Formula	C42H65N11O12S2
Sequences	APDVQDCPECTLQENPFFSQPGAPILQCMGCCFSRAYPTPLRSKKTMLVQKNVTSESTCCVAKSYNRVTVMGGFKVENHTACHCSTCYYHKSNSCELTNITIAIEKEECRFCISINTTWCAGYCYTRDLVYKDPARPKIQKTCTFKELVYETVRVPGCAHHADSLYTYPVATQCHCGKCDSDSTDCTVRGLGPSYCSFGEMKE
CAS No.	97048-13-0
Molecular Weight	980.162 Da
Synonyms	Follitropin human; Urofollitrophin
Applications info	For treatment of female infertility.
Examples of Clinical Use	Female infertility
Pharmacodynamics	Used for the treatment of female infertility, the product or follicle stimulating hormone (FSH) stimulates ovarian follicular growth in women who do not have primary ovarian failure. FSH, the active component of the product is the primary hormone responsible for follicular recruitment and development.
Mechanism of action	FSH binds to the follicle stimulating hormone receptor which is a G-coupled transmembrane receptor. Binding of the FSH to its receptor seems to induce phosphorylation and activation of the PI3K (Phosphatidylinositol-3-kinase) and Akt signaling pathway, which is known to regulate many other metabolic and related survival/maturation functions in cells.
Affected organisms	Humans and other mammals
Targets	Target 1. Follicle-stimulating hormone receptor

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Menge: 1ea

Listenpreis: 4.545,00 €

Preis: 4.545,00 €

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