Recombinant Mouse B7-H2/ICOS Ligand/CD275 Protein

Mouse ICOS ligand(B7-H2) is an approximately transmembrane glycoprotein in the B7 family of immuneregulatory molecules. B7-H2 is expressed on antigen presenting cells such as B cells, macrophages, monocytes, and dendritic cells. It binds to ICOS on activated T cells, leading to both positive and negative effects onimmune responses including its own down-regulation. The B7-H2 interaction with ICOS is costimulatory for Tcell proliferation as well as the development of B cells, plasma cells, follicular helper T cells and germinalcenters. B7-H2 contributes to the development of allergic asthma by enhancing Th2 biased immune responses, limiting Th17 responses, and promoting eosinophilic infiltration into the lung. Its activation of ICOS on Treglimits pulmonary inflammation and airway hyperresponsiveness, promotes the development of inhalationaltolerance, and impairs antitumor immunity. In the thyroid, B7-H2 is up-regulated on thyrocytes duringinflammation and promotes their proliferation and production of thryoid hormones.

Proteins

Glu47-Lys279

Immune Checkpoint

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.Contact us for customized product form or formulation.