HVEM Recombinant Protein

This recombinant protein can be used for E, WB. For research use only.

Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.

19.2 kDa

Herpesvirus entry mediator (HVEM) is also known as TNFRSF14, TR2 (TNF receptorlike molecule) and ATAR (another TRAF associated receptor), is a type I membrane protein belonging to the TNF/NGF receptor superfamily. HVEM expression has been detected in peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells. The extracellular domain of HVEM has been shown to interact directly with the herpes simplex virus envelope glycoprotein D (gD). Two TNF superfamily ligands, including the secreted TNFbeta (lymphotoxin alpha) and the membrane protein LIGHT (lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes), have been shown to be the cellular ligands for HVEM. Besides HVEM, LIGHT can also interact with LTbetaR, the receptor for lymphotoxin alphabeta heterotrimer. The role of the HVEM LIGHT /LTbeta receptor ligand pair in immune function and herpesvirus pathobiology remains to be elucidated.

Hsu, H. et al., 1997, J. Biol. Chem. 272:13471.

Montgomery, R.I. et al., 1996, Cell 87:427.

NP_003811

HVEM

Homo sapiens

His Tag

Measured by its binding ability in a functional ELISA. Immobilized Human HVEM, His Tag at 0.5 ug/mL (100 uL/well) can bind Human BTLA, Fc Tag with a linear range of 0.078-2.5 ug/mL.