IL-17A Recombinant Protein

This product is for research use only.

The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant human IL-17A is a 31.0 kDa disulfide-linked homodimer of two 136 amino acid polypeptide chains. Manufactured using all non-animal reagents.

3605

interleukin 17A

Q16552

Assay 1: Determined by the dose-dependent induction of IL-6 in primary human foreskin fibroblast. The expected ED50is ≤ 2.0 ng/mL, corresponding to a specific activity of ≥ 5 x 10⁵ units/mg.

Assay 2: Measured by its ability to induce IL-6 production by NHDF cells.

MIVKAGITIP RNPGCPNSED KNFPRTVMVN LNIHNRNTNT NPKRSSDYYN RSTSPWNLHR NEDPERYPSV IWEAKCRHLG CINADGNVDY HMNSVPIQQE ILVLRREPPH CPNSFRLEKI LVSVGCTCVT PIVHHVA