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Recombinant human HSP27 protein

Recombinant human HSP27 protein

147,00 €

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ArtNr	NKM-HSP0503-20ug
Hersteller	NKMAX
Menge	20ug
Kategorie	Peptides & Proteins Recombinant Proteins SDS-PAGE
Typ	Proteins Recombinant
Applikationen	SDS-PAGE
Specific against	other
Konjugat/Tag	Non-Tagged
Purity	> 95% by SDS-PAGE
Citations	Kaiser F, et al. Monocyte cytokine synthesis in response to extracellular cell stress proteins suggests these proteins exhibit network behaviour. Cell Stress Chaperones. 2014 Jan;19(1):135-44.{https://pubmed.ncbi.nlm.nih.gov/23775284/} Casola C, et al. S100 alone has the same destructive effect on retinal ganglion cells as in combination with HSP 27 in an autoimmune glaucoma model. J Mol Neurosci. 2015 May;56(1):228-36.{https://pubmed.ncbi.nlm.nih.gov/25577368/} Reinehr S, et al. HSP27 immunization reinforces AII amacrine cell and synapse damage induced by S100 in an autoimmune glaucoma model. Cell Tissue Res. 2018 Feb;371(2):237-249.{https://pubmed.ncbi.nlm.nih.gov/29064077/} Grotegut P, et al. Destructive Effect of Intravitreal Heat Shock Protein 27 Application on Retinal Ganglion Cells and Neurofilament. Int J Mol Sci. 2020 Jan 15;21(2):549.{https://pubmed.ncbi.nlm.nih.gov/31952234/} Eickholz P, et al. Effect of nonsurgical periodontal therapy on haematological parameters in grades B and C periodontitis: an exploratory analysis. Clin Oral Investig. 2020 Dec;24(12):4291-4299. {} Grotegut P, et al. Heat Shock Protein 27 Injection Leads to Caspase Activation in the Visual Pathway and Retinal T-Cell Response. Int J Mol Sci. 2021 Jan 6;22(2):513.{https://pubmed.ncbi.nlm.nih.gov/33419223/}
NCBI	NP_001531
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Heat shock 27 kDa protein, Hspb1, Hsp25, Hsp27, Hsp27, HspB1, Heat shock 27 kDa protein, HSP 27, Growth-related 25 kDa protein, P25, HSP25, Heat shock protein beta-1, Heat shock 27 kDa protein 28 kDa heat shock protein, CMT2F, DKFZp586P1322, Estrogen regulated 24 kDa protein, at shock 25kDa protein 1, Heat shock 27kDa protein 1, Heat shock 28kDa protein 1, Heat Shock Protein 27, Heat shock protein beta 1, Heat Shock Protein27, HS.76067, Hsp 28, Hsp B1, Hsp28, HspB1, SRP27, Stress responsive protein 27.
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Antigen Species	Human
Bioassay Procedure	MTERRVPFSL LRGPSWDPFR DWYPHSRLFD QAFGLPRLPE EWSQWLGGSS WPGYVRPLPP AAIESPAVAA PAYSRALSRQ LSSGVSEIRH TADRWRVSLD VNHFAPDELT VKTKDGVVEI TGKHEERQDE HGYISRCFTR KYTLPPGVDP TQVSSSLSPE GTLTVEAPMP KLATQSNEIT IPVTFESRAQ LGGPEAAKSD ETAAK
Concentration	1mg/ml (determined by Bradford assay)
Description	Hsp27 (also known as the Estrogen-Regulated 24K protein, and hsp 28) is a member of the mammalian small heat shock protein family. Hsp27 is expressed constitutively in many tissues and its expression is increased to high levels after various types of stress including elevated temperatures, toxic metals, drugs and oxidants. Also, Hsp27 is phosphorylated in vivo on three phosphorylation sites (Ser15, Ser78 and Ser82) by protein kinases including MAPKAP kinase 2 and the stress-activated protein kinase SAPK2 (p38). Recombinant human Hsp27 was overexpressed in E. coli and purified by conventional chromatography.
Domain	1-205aa
Endotoxin	< 1 EU per 1ug of protein (determined by LAL method)
Expression System	E.coli
Formulation	Liquid in. 20mM HEPES buffer (pH 7.4) containing 100mM KCl, 1mM DTT
Gene Category	Heat Shock Proteins
General References	Ehrnsperger M., et al. (1997) EMBO J. 16, 221-229; ; Butt E., et al. (2001) J. Biol. Chem. 276, 7108-7113; ;
Molecular Weight	22.7 kDa (205aa) confirmed by MALDI-TOF

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Menge: 20ug

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Preis: 147,00 €

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