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Recombinant human PKM2 protein

Recombinant human PKM2 protein

725,00 €

Zzgl. MwSt.

ArtNr	NKM-ATGP0429-500ug
Hersteller	NKMAX
Menge	500ug
Kategorie	Oncology Metabolism Glucose Homeostasis Assisted reproductive technologies Embryo manipulation Peptides & Proteins Recombinant Proteins SDS-PAGE By Organ Thyroid Cancer
Typ	Proteins Recombinant
Applikationen	SDS-PAGE
Specific against	other
Konjugat/Tag	His-Tag
Purity	> 95% by SDS-PAGE
NCBI	NP_002645
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	PKM2, pyruvate kinase muscle isoform M2, CTHBP, THBP1, p58, M2-PK, Tumor M2-PK, PK2, PK3, PKM, pyruvate kinase, muscle isoform M2 OIP3, PKM, TCB, OPA interacting protein 3, PKM2, Cytosolic thyroid hormone binding protein, Pyruvate kinase 2/3, Pyruvate kinase isozymes M1/M2, Pyruvate kinase muscle, Thyroid hormone binding protein cytosolic, Tumour Type M2 Pyruvate Kinase, Tumor Type M2 Pyruvate Kinase
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Antigen Species	Human
Bioactivity Comment Only	Specific activity: > 25, 000pmol/min/ug. One unit will convert 1.0pmole of phospho(enol)pyruvate to pyruvate per minute at pH 7.5 at 37C.
Concentration	1mg/ml (determined by Bradford assay)
Description	PKM2 is an isoenzyme of the glycolytic enzyme pyruvate kinase. This protein catalyzes the production of pyruvate and ATP from phosphoenolpyruvate. PKM2 interacting with Opa proteins, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, is required for bacterial pathogenesis. It is specifically expressed at high levels in tumor cells, and can be measured in plasma of patients with advanced breast cancer. Recombinant human PKM2, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Endotoxin	< 1 EU per 1ug of protein (determined by LAL method)
Expression System	E.coli
Formulation	Liquid in. 20mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Gene Category	Cancer
General References	Zwerschke W., et al. (2009). Exp Cell Res. 315(16):2765-74; ; Mazurek S., et al. (2007). Ernst Schering Found Symp Proc. (4):99-124.; ;
Molecular Weight	60.1 kDa (551aa)
Storage	Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

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Menge: 500ug

Listenpreis: 725,00 €

Preis: 725,00 €

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