Human CTLA-4 Protein, mFc-His Tag

Blue Ice

Store at -80C for 12 months (Avoid repeated freezing and thawing)

Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 24 % trehalose is added as protectants before lyophilization.

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

P16410

CTLA-4

HEK293

> 95%

CTLA-4(Gln36-Ser161)+mFc(Pro99-Lys330)+6xHis