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Human ACE2 / ACEH Protein, Fc Tag (MALS verified)

Human ACE2 / ACEH Protein, Fc Tag (MALS verified)

1.085,00 €

Zzgl. MwSt.

ArtNr	AC2-H5255-200ug
Hersteller	ACROBiosystems
Menge	200ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins Recombinant
Format	Liquid
Specific against	Human (Homo sapiens)
Konjugat/Tag	Fc
Purity	>95% as determined by SDS-PAGE.
Dry ice	Yes
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Lieferbar
Bioactivity Legend 1	Immobilized Human ACE2, Fc Tag (Cat. No. AC2-H5255) at 2 ?g/mL (100 ?L/well) can bind Biotinylated SARS-CoV-2 S1 protein, His, Avitag (Cat. No. S1N-C82E8) with a linear range of 40-625 ng/mL (QC tested).
Buffer	PBS, pH7.4
Characteristics	This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 110.0 kDa. As a result of glycosylation, the protein migrates as 125-150 kDa under reducing (R) condition, and 250-300 kDa under non-reducing (NR) condition (SDS-PAGE).
Description	Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. ACE2 may be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses. ACE2 is activated by chloride and fluoride, but not bromide and Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. ACE2 is active from pH 6 to 9, and the optimum pH is 6.5 in the presence of 1 M NaCl.
Endotoxin Level	Less than 1.0 EU per ?g by the LAL method.
Expression System	HEK293
Molecular Weight	110.0 kDa
Molecule	ACE2
SDS-PAGE Legend	Human ACE2, Fc Tag on SDS-PAGE under reducing (R) and non-reducing (NR) conditions. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%.
Storage	-70?

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Menge: 200ug

Listenpreis: 1.085,00 €

Preis: 1.085,00 €

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Lieferung vsl. bis 07.08.2025

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