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Recombinant Mouse Interleukin-20

Recombinant Mouse Interleukin-20

7.274,00 €

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ArtNr	cyt-379-1mg
Hersteller	ProSpec
Menge	1mg
Kategorie	Neuroscience Neural Lineage Markers Neural Transcription Factors Peptides & Proteins Recombinant Proteins
Typ	Cytokines and Growth Factors
Specific against	Mouse (Murine, Mus musculus)
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Similar products	mIL 20
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Synonyms	IL10D, ZCYTO10, IL-20, MGC96907, Four alpha helix cytokine Zcyto10
Introduction	IL20 is a cytokine structurally related to interleukin 10 (IL10). IL20 cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.
Description	Interleukin-20 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 152 amino acids and having a total molecular mass of 17, 584 Dalton. The IL-20 is purified by proprietary chromatographic techniques.
Source	Escherichia Coli.
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation	Lyophilized from a concentrated (1mg/ml) solution containing no additives.
Purity	Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Amino acid sequence	The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Lys-Thr-Leu.
Biological Activity	The biological activity was determined by measuring the dose dependent activation of STAT3 in human epidermal keratinocytes (HEK2a cells). Significant STAT3 activation is observed with 100ng/mL of Interleukin-20 recombinant mouse, corresponding to a specific activity of 10, 000 units/mg of Interleukin-20 recombinant mouse.
Storage	Lyophilized Interleukin-20 although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution IL20 should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

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cyt-379-1mg-safety-datasheet.pdf