Recombinant Human Interleukin-8 (1-77) (CXCL8)

Interleukin-8 (IL-8) is a chemokine produced by macrophages and other cell types such as epithelial cells. It is also synthesized by endothelial cells, which store IL-8 in their storage vesicles, the Weibel-Palade bodies. When first encountering an antigen, the primary cells to encounter it are the macrophages who phagocytose the particle. Upon processing, they release chemokines to signal other immune cells to come in to the site of inflammation. IL-8 is one such chemokine. It serves as a chemical signal that attracts neutrophils at the site of inflammation, and therefore is also known as Neutrophil Chemotactic Factor.

Escherichia Coli.

Lyophilized from a0.2um filtered concentrated (1mg/ml) solution in PBS, pH 7.4.

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Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 25-150 ng/ml.