Recombinant Human IL-17A/CTLA-8 Protein

IL17, also known as IL17a, is a cytokine that belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis.

Proteins

Ile20-Ala155

Other Recombinant Protein

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

1.Measured by its ability to induce IL-6 secretion by HeLa human cervical epithelial carcinoma cells. The ED₅₀ for this effect is 7.91-31.64 ng/mL.|2.Measured by its binding ability in a functional ELISA.Immobilized Human IL17RA at 1 μg/mL (100 μL/well) can bind Human IL17A with a linear range of 0.2-15.8 ng/mL.